A DNA-binding Gd chelate for the detection of cell death by MRI.
نویسندگان
چکیده
GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate.
منابع مشابه
Molecular MRI of acute necrosis with a novel dna-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium
BACKGROUND Current techniques to image cell death in the myocardium are largely nonspecific. We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic (ruptured) cells in vivo. METHODS AND RESULTS In vivo MRI was performed in 20 mice with myocardial infarction (MI). The mice were injected with Gd-TO or Gd-DTPA at varying tim...
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ورودعنوان ژورنال:
- Chemical communications
دوره 29 شماره
صفحات -
تاریخ انتشار 2009